Microfluidic approaches for cancer cell detection, characterization, and separation

J Chen, J Li, Y Sun - Lab on a Chip, 2012‏ - pubs.rsc.org
This article reviews the recent developments in microfluidic technologies for in vitro cancer
diagnosis. We summarize the working principles and experimental results of key microfluidic …

Recent advances in microfluidic techniques for single-cell biophysical characterization

Y Zheng, J Nguyen, Y Wei, Y Sun - Lab on a Chip, 2013‏ - pubs.rsc.org
Biophysical (mechanical and electrical) properties of living cells have been proven to play
important roles in the regulation of various biological activities at the molecular and cellular …

Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization

J Chen, C Xue, Y Zhao, D Chen, MH Wu… - International journal of …, 2015‏ - mdpi.com
This article reviews recent developments in microfluidic impedance flow cytometry for high-
throughput electrical property characterization of single cells. Four major perspectives of …

Microbial analysis in dielectrophoretic microfluidic systems

RE Fernandez, A Rohani, V Farmehini, NS Swami - Analytica chimica acta, 2017‏ - Elsevier
Infections caused by various known and emerging pathogenic microorganisms, including
antibiotic-resistant strains, are a major threat to global health and well-being. This highlights …

Cell manipulation and single cell characterization on microfluidic devices

Y Wu, Y Meng - TrAC Trends in Analytical Chemistry, 2023‏ - Elsevier
Cell is the structural and functional unit of life. The manipulation of fluids and cells is of vital
importance in biotechnology, chemistry and biomedical areas. Microfluidics has provided a …

Dielectric measurement of cell death

P Patel, GH Markx - Enzyme and microbial technology, 2008‏ - Elsevier
Dielectric techniques, which include dielectric spectroscopy as well as AC electrokinetic
methods such as dielectrophoresis, electrorotation and electro-orientation, can be provide …

Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach

EA Henslee, RMT Serrano, FH Labeed, RI Jabr, CH Fry… - Analyst, 2016‏ - pubs.rsc.org
A loss of ability of cells to undergo apoptosis (programmed cell death, whereby the cell
ceases to function and destroys itself) is commonly associated with cancer, and many anti …

Cancer, pre-cancer and normal oral cells distinguished by dielectrophoresis

HJ Mulhall, FH Labeed, B Kazmi, DE Costea… - Analytical and …, 2011‏ - Springer
Most oral cancers are oral squamous cell carcinomas (OSCC) that arise from the epithelial
lining of the oral mucosa. Given that the oral cavity is easily accessible, the disease lends …

Ten–Second Electrophysiology: Evaluation of the 3DEP Platform for high-speed, high-accuracy cell analysis

KF Hoettges, EA Henslee, RM Torcal Serrano… - Scientific reports, 2019‏ - nature.com
Electrical correlates of the physiological state of a cell, such as membrane conductance and
capacitance, as well as cytoplasm conductivity, contain vital information about cellular …

Differences in the biophysical properties of membrane and cytoplasm of apoptotic cells revealed using dielectrophoresis

FH Labeed, HM Coley, MP Hughes - Biochimica et Biophysica Acta (BBA) …, 2006‏ - Elsevier
We have used dielectrophoresis to determine the dielectric properties of human chronic
myelogeneous leukaemic (K562) cells during apoptosis (programmed cell death). Our …