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The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives
S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …
correspondence between disease mortality and incidence. Furthermore, it is usually …
Detecting liquid remnants of solid tumors: circulating tumor DNA minimal residual disease
Growing evidence demonstrates that circulating tumor DNA (ctDNA) minimal residual
disease (MRD) following treatment for solid tumors predicts relapse. These results suggest …
disease (MRD) following treatment for solid tumors predicts relapse. These results suggest …
Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
L Buscail, B Bournet, P Cordelier - Nature reviews Gastroenterology & …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …
cause of death within the next 10 years. The prognosis for this disease is poor despite …
Circulating tumor DNA analysis in patients with cancer: American Society of Clinical Oncology and College of American Pathologists joint review
Purpose.—Clinical use of analytical tests to assess genomic variants in circulating tumor
DNA (ctDNA) is increasing. This joint review from the American Society of Clinical Oncology …
DNA (ctDNA) is increasing. This joint review from the American Society of Clinical Oncology …
Circulating tumor DNA analyses as markers of recurrence risk and benefit of adjuvant therapy for stage III colon cancer
Importance Adjuvant chemotherapy in patients with stage III colon cancer prevents
recurrence by eradicating minimal residual disease. However, which patients remain at high …
recurrence by eradicating minimal residual disease. However, which patients remain at high …
Liquid biopsy: general concepts
G Poulet, J Massias, V Taly - Acta cytologica, 2019 - karger.com
Liquid biopsy provides the opportunity of detecting, analyzing and monitoring cancer in
various body effluents such as blood or urine instead of a fragment of cancer tissue. It is …
various body effluents such as blood or urine instead of a fragment of cancer tissue. It is …
Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges
Circulating tumor DNA (ctDNA) has emerged as a biomarker with wide-ranging applications
in cancer management. While its role in guiding precision medicine in certain tumors via …
in cancer management. While its role in guiding precision medicine in certain tumors via …
Circulating nucleic acids are associated with outcomes of patients with pancreatic cancer
Background & Aims We aimed to investigate the clinical utility of circulating tumor cell DNA
(ctDNA) and exosome DNA (exoDNA) in pancreatic cancer. Methods We collected liquid …
(ctDNA) and exosome DNA (exoDNA) in pancreatic cancer. Methods We collected liquid …
Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study
Objective For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy
selection following surgery remains a major clinical dilemma. Here, we investigated the …
selection following surgery remains a major clinical dilemma. Here, we investigated the …
Circulating tumor DNA in advanced solid tumors: clinical relevance and future directions
The application of genomic profiling assays using plasma circulating tumor DNA (ctDNA) is
rapidly evolving in the management of patients with advanced solid tumors. Diverse plasma …
rapidly evolving in the management of patients with advanced solid tumors. Diverse plasma …