The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Detecting liquid remnants of solid tumors: circulating tumor DNA minimal residual disease

EJ Moding, BY Nabet, AA Alizadeh, M Diehn - Cancer discovery, 2021 - aacrjournals.org
Growing evidence demonstrates that circulating tumor DNA (ctDNA) minimal residual
disease (MRD) following treatment for solid tumors predicts relapse. These results suggest …

Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer

L Buscail, B Bournet, P Cordelier - Nature reviews Gastroenterology & …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …

Circulating tumor DNA analysis in patients with cancer: American Society of Clinical Oncology and College of American Pathologists joint review

JD Merker, GR Oxnard, C Compton… - … of pathology & …, 2018 - meridian.allenpress.com
Purpose.—Clinical use of analytical tests to assess genomic variants in circulating tumor
DNA (ctDNA) is increasing. This joint review from the American Society of Clinical Oncology …

Circulating tumor DNA analyses as markers of recurrence risk and benefit of adjuvant therapy for stage III colon cancer

J Tie, JD Cohen, Y Wang, M Christie, K Simons… - JAMA …, 2019 - jamanetwork.com
Importance Adjuvant chemotherapy in patients with stage III colon cancer prevents
recurrence by eradicating minimal residual disease. However, which patients remain at high …

Liquid biopsy: general concepts

G Poulet, J Massias, V Taly - Acta cytologica, 2019 - karger.com
Liquid biopsy provides the opportunity of detecting, analyzing and monitoring cancer in
various body effluents such as blood or urine instead of a fragment of cancer tissue. It is …

Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges

E Sanz-Garcia, E Zhao, SV Bratman, LL Siu - Science Advances, 2022 - science.org
Circulating tumor DNA (ctDNA) has emerged as a biomarker with wide-ranging applications
in cancer management. While its role in guiding precision medicine in certain tumors via …

Circulating nucleic acids are associated with outcomes of patients with pancreatic cancer

V Bernard, DU Kim, FA San Lucas, J Castillo… - Gastroenterology, 2019 - Elsevier
Background & Aims We aimed to investigate the clinical utility of circulating tumor cell DNA
(ctDNA) and exosome DNA (exoDNA) in pancreatic cancer. Methods We collected liquid …

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

J Tie, JD Cohen, Y Wang, L Li, M Christie, K Simons… - Gut, 2019 - gut.bmj.com
Objective For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy
selection following surgery remains a major clinical dilemma. Here, we investigated the …

Circulating tumor DNA in advanced solid tumors: clinical relevance and future directions

ML Cheng, E Pectasides, GJ Hanna… - CA: a cancer journal …, 2021 - Wiley Online Library
The application of genomic profiling assays using plasma circulating tumor DNA (ctDNA) is
rapidly evolving in the management of patients with advanced solid tumors. Diverse plasma …