Vaccines for established cancer: overcoming the challenges posed by immune evasion

SH van der Burg, R Arens, F Ossendorp… - Nature Reviews …, 2016 - nature.com
Therapeutic vaccines preferentially stimulate T cells against tumour-specific epitopes that
are created by DNA mutations or oncogenic viruses. In the setting of premalignant disease …

The peptide vaccine of the future

A Nelde, HG Rammensee, JS Walz - Molecular & cellular proteomics, 2021 - ASBMB
The approach of peptide-based anticancer vaccination has proven the ability to induce
cancer-specific immune responses in multiple studies for various cancer entities. However …

Mechanisms of action of adjuvants

S Awate, LA Babiuk, G Mutwiri - Frontiers in immunology, 2013 - frontiersin.org
Adjuvants are used in many vaccines, but their mechanisms of action are not fully
understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the …

Heterologous protection against influenza by injection of DNA encoding a viral protein

JB Ulmer, JJ Donnelly, SE Parker, GH Rhodes… - Science, 1993 - science.org
Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different
strains of virus, in contrast to antibodies, which are generally strain-specific. The generation …

Lipopeptides: from self-assembly to bioactivity

IW Hamley - Chemical Communications, 2015 - pubs.rsc.org
This Feature Article discusses several classes of lipopeptide with important biomedical
applications as antimicrobial and antifungal agents, in immune therapies and in personal …

Induction of virus‐specific cytotoxic T lymphocytes in vivo by liposome‐entrapped mRNA

F Martinon, S Krishnan, G Lenzen… - European journal of …, 1993 - Wiley Online Library
The induction of anti‐influenza cytotoxic T lymphocytes (CTL) in vivo by immunizing mice
with liposomes containing messenger RNA (mRNA) encoding the influenza virus …

TLR-based immune adjuvants

F Steinhagen, T Kinjo, C Bode, DM Klinman - Vaccine, 2011 - Elsevier
This work describes the nature and strength of the immune response induced by various Toll-
like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various …

Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant

MG Revello, G Gerna - Clinical microbiology reviews, 2002 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection and
mental retardation. HCMV infection, while causing asymptomatic infections in most …

Engineered nucleic acids encoding a modified erythropoietin and their expression

JP Schrum, NB Afeyan, GJ Sieczkiewicz… - US Patent …, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

SA Rosenberg, JC Yang, DJ Schwartzentruber… - Nature medicine, 1998 - nature.com
The cloning of the genes encoding cancer antigens has opened new possibilities for the
treatment of patients with cancer. In this study, immunodominant peptides from the gp100 …