Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano [2, 3-d] pyrimidine core

AY El-Khateeb, SE Hamed, KM Elattar - RSC advances, 2022 - pubs.rsc.org
Heterocyclic compounds incorporated with a pyranopyrimidine skeleton have received
substantial consideration owing to their privileged, and intelligible biodiversity. Accordingly …

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

A Rezaeifard, M Bakherad, L Navidpour… - …, 2024 - Wiley Online Library
Due to their extensive applications in pharmaceuticals and natural substances, organic
synthesis and heterocyclic compounds have been at the forefront of research for many …

Fabrication of heterogeneous-based lacunary polyoxometalates as efficient catalysts for the multicomponent and clean synthesis of pyrazolopyranopyrimidines

Z Yekke-Ghasemi, MM Heravi, M Malmir… - Inorganic Chemistry …, 2022 - Elsevier
In continues efforts to the synthesis of polyoxometalate (POM) as catalysts, two lacunary
POM-based heterogeneous catalysts (TBA) 9 [BW 11 O 39]· 11H 2 O ((TBA) 9 BW 11) and …

[HTML][HTML] The curative activity of some arylidene dihydropyrimidine hydrazone against Tobacco mosaic virus infestation

AZ Omar, E Hamdy, EA Hamed, E Hafez… - Journal of Saudi …, 2022 - Elsevier
A series of novel pyrimidine-based derivative compounds were synthesized and evaluated
for antiviral activity against Tobacco mosaic virus (TMV). All chemical structures of the …

Fabrication of UiO-66 nanocages confined brønsted ionic liquids as an efficient catalyst for the synthesis of dihydropyrazolo [4′, 3': 5, 6] pyrano [2, 3-d] pyrimidines

Z Mahmoudi, MA Ghasemzadeh… - Journal of Molecular …, 2019 - Elsevier
In this study, a novel, simple and efficient procedure to confine Brønsted acid ionic liquids
(TEDA/IMIZ-BAIL) in the cages of UiO-66 metal-organic frameworks was introduced. The …

A multi-functional composite nanocatalyst for the synthesis of biologically active pyrazolopyranopyrimidines: Multifaceted antimicrobial, antioxidant, and anticancer …

Y Xu, SM Nezhad, EN Zare, SA Pourmousavi… - … Composites and Hybrid …, 2025 - Springer
Metal-organic frameworks (MOFs) are crystalline entities made up of metal ions or clusters
coordinated to typically rigid organic molecules, creating three-dimensional porous …

Synthesis, biological evaluation and molecular docking study of 1, 2, 3-1H-triazoles having 4H-pyrano [2, 3-d] pyrimidine as potential Mycobacterium tuberculosis …

ND Thanh, NTT Ha, CT Le, HTK Van, VN Toan… - Bioorganic & medicinal …, 2019 - Elsevier
Abstract Some heterocycles, namely 2-amino-4H-pyran-3-carbonitriles, were synthesized in
a three-component reaction from substituted benzaldehydes, malononitrile, and ethyl …

An insight on medicinal attributes of pyrimidine scaffold: An updated review

A Vyas, B Sahu, S Pathania, NK Nandi… - Journal of …, 2023 - Wiley Online Library
Pyrimidine itself or in different fused forms is an important chemical motif for every step of
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …

[HTML][HTML] Proficient synthesis of bioactive annulated pyrimidine derivatives: A review

AR Bhat, RS Dongre, GA Naikoo, IU Hassan… - Journal of Taibah …, 2017 - Elsevier
Syntheses of bioactive annulated pyrimidine derivatives are the most significant tasks in N-
heterocyclic chemistry because these compounds have proved to be very attractive and …

Synthesis and in Silico Antiviral Activity of Novel Bioactive Thiobarbituric Acid Based Hydrazones and Pyrazoles against SARS-CoV-2 Main Protease (Mpro)

TZ Abolibda, M Fathalla, GF Aljohani… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Owing to its broad spectrum biological activity, pyrimidines have been extensively employed
as building blocks for synthesizing various drug mimic molecules. In the present work, a …