Mesenchymal stem/stromal cells in cancer therapy

T Lan, M Luo, X Wei - Journal of Hematology & Oncology, 2021 - Springer
The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone
marrow in 1976, have been identified in nearly all tissues of human body now. The …

Tumor microenvironment promotes breast cancer chemoresistance

U Mehraj, AH Dar, NA Wani, MA Mir - Cancer chemotherapy and …, 2021 - Springer
Breast cancer is presently the most predominant tumor type and the second leading cause
of tumor-related deaths among women. Although advancements in diagnosis and …

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

S Nath, GR Devi - Pharmacology & therapeutics, 2016 - Elsevier
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …

Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells

JK Lee, SR Park, BK Jung, YK Jeon, YS Lee, MK Kim… - PloS one, 2013 - journals.plos.org
Exosomes are small membrane vesicles released by a variety of cell types. Exosomes
contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they …

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

MA Chiurillo - World journal of experimental medicine, 2015 - pmc.ncbi.nlm.nih.gov
Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

S Liu, C Ginestier, SJ Ou, SG Clouthier, SH Patel… - Cancer …, 2011 - aacrjournals.org
We have used in vitro and mouse xenograft models to examine the interaction between
breast cancer stem cells (CSC) and bone marrow–derived mesenchymal stem cells (MSC) …

Double‐edged sword of mesenchymal stem cells: cancer‐promoting versus therapeutic potential

HY Lee, IS Hong - Cancer science, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, cord blood, and
other tissues, have recently attracted much attention as potential therapeutic agents in …

Mesenchymal stromal cells in cancer: a review of their immunomodulatory functions and dual effects on tumor progression

S Galland, I Stamenkovic - The Journal of pathology, 2020 - Wiley Online Library
Mesenchymal stem or stromal cells (MSCs) are pluripotent cells implicated in a broad range
of physiological events, including organogenesis and maintenance of tissue homeostasis as …

Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?

AH Klopp, A Gupta, E Spaeth, M Andreeff… - Stem cells, 2011 - academic.oup.com
The discovery that mesenchymal stem cells (MSCs) are recruited into tumors has led to a
great deal of interest over the past decade in the function of MSCs in tumors. To address …

Stem cells as drug delivery methods: application of stem cell secretome for regeneration

C Tran, MS Damaser - Advanced drug delivery reviews, 2015 - Elsevier
Mesenchymal stem cells (MSCs) are a unique cell population defined by their ability to
indefinitely self-renew, differentiate into multiple cell lineages, and form clonal cell …