Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …

Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …

Evidence is mounting that the gut-brain axis plays an important role in mental diseases
fueling mechanistic investigations to provide a basis for future targeted interventions …

The microbiome-gut-brain axis plays a role in anxiety, the stress response and social
development, and is of growing interest in neuropsychiatric conditions. The gut microbiota …

The importance of tryptophan as a precursor for neuroactive compounds has long been
acknowledged. The metabolism of tryptophan along the kynurenine pathway and its …

L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an
extensive and complex metabolism along several pathways, resulting in many bioactive …