Since their discovery over 100 years ago cyclodextrins (CDs) have been the subject of
numerous scientific publications. In 2016 alone CDs were the subject of over 2200 research …

Although cyclodextrins (CDs) have been studied for over 100 years and can be found in at
least 35 pharmaceutical products, they are still regarded as novel pharmaceutical …

Abstract The Biopharmaceutics Classification System (BCS) has found widespread utility in
drug discovery, product development and drug product regulatory sciences. The …

Cyclodextrins have gained currency as useful solubilizing excipients with an ever increasing
list of beneficial properties and functionalities. Although their use in liquid dosage forms …

The objective of this study was to investigate the pH-dependent solubility and dissolution of
weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized …

The number of poorly water-soluble drug candidates is rapidly increasing; this represents a
major challenge for the pharmaceutical industry. As a consequence, novel formulation …

Cyclodextrins (CDs) are enabling pharmaceutical excipients that can be found in numerous
pharmaceutical products worldwide. Because of their favorable toxicologic profiles, CDs are …

Carvedilol, a β-blocker prescribed for chronic heart failure, suffers from poor bioavailability
and rapid first pass metabolism when administered orally. Herein, we present the …

Sažetak This commentary addresses data quality in equilibrium solubility measurement in
aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to …

Cyclodextrins (CDs) are widely used in pharmaceutical products for improving the solubility
and bioavailability of drugs through the formation of water-soluble inclusion complexes …