Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Life, as a dense manifestation of soft matter, undergoes changes in water content,
biomacromolecular concentrations, condensation and crowding due to volumetric …

The mechanical properties of biological tissues have emerged as an integral determinant of
tissue function in health and disease. Nonetheless, characterizing the elasticity of biological …

The physical microenvironment plays a crucial role in tumor development, progression,
metastasis and treatment. Recently, we proposed four physical hallmarks of cancer, with …

Cell–matrix interactions, mediated by cellular force and matrix remodeling, result in dynamic
reciprocity that drives numerous biological processes and disease progression. Currently …

Mechanical forces are key regulators of cellular behavior and function, affecting many
fundamental biological processes such as cell migration, embryogenesis, immunological …

The bottleneck of traditional anti-tumor therapy is mainly limited by the abnormal
microenvironment of tumors. Leaky vessels are difficult for drugs or immune cells to …

Cells and tissues are often under some level of confinement, imposed by the
microenvironment and neighboring cells, meaning that there are limitations to cell size …

Lung diseases such as cancer substantially alter the mechanical properties of the organ with
direct impact on the development, progression, diagnosis, and treatment response of …

Solid stress, originating from rigid and elastic components of extracellular matrix and cells, is
a typical physical hallmark of tumors. Mounting evidence indicates that elevated solid stress …