In the brain, mitochondrial metabolism has been largely associated with energy production,
and its dysfunction is linked to neuronal cell loss. However, the functional role of …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of
ions and small molecules. Initially described as low-resistance ion pathways joining …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Gap junctions allow the exchange of ions, second messengers, and small metabolites
between adjacent cells and are formed by two unrelated protein families, the pannexins and …

Glutamate excitotoxicity, oxidative stress, and acidosis are primary mediators of neuronal
death during ischemia and reperfusion. Astrocytes influence these processes in several …

Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The
first observation of second messenger junctional permeability, made∼ 30 years ago …

Gap junctions form channels between adjacent cells. The core proteins of these channels
are the connexins. Regulation of gap junction communication (GJC) can be modulated by …

Cxs (connexins), the protein subunits forming gap junction intercellular communication
channels, are transported to the plasma membrane after oligomerizing into hexameric …