Angiotensin-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase and
is crucial in the renin-angiotensin-aldosterone system (RAAS) but also implicated in immune …

The observation that all components of the renin angiotensin system (RAS) are expressed in
the kidney and the fact that intratubular angiotensin (Ang) II levels greatly exceed the plasma …

Granulocytes are key players in cancer metastasis. While tumor-induced de novo expansion
of immunosuppressive myeloid-derived suppressor cells (MDSCs) is well-described, the fate …

Aims The metabolic failure of macrophages to adequately process lipid is central to the
aetiology of atherosclerosis. Here, we examine the role of macrophage angiotensin …

To understand how kidney donation leads to an increased risk of preeclampsia, we studied
pregnant outbred mice with prior uninephrectomy and compared them with sham-operated …

Angiotensin-converting enzyme inhibitors (ACEIs) are used by millions of patients to treat
hypertension, diabetic kidney disease, and heart failure. However, these patients are often …

Hypertension (high blood pressure) is a major risk factor for cardiovascular disease, which is
the leading cause of death worldwide. The somatic isoform of angiotensin I‐converting …

Abstract Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, plays a major role in
the regulation of blood pressure by cleaving angiotensin I into angiotensin II (Ang II), a …

Creatine is an indispensable organic compound utilized in physiological environments;
however, its role in immunity is still poorly understood. Here, we show that creatine …

Hypertension remains the leading preventable risk factor for stroke and coronary artery
disease, significantly contributing to all-cause global mortality and predisposing patients to …