Hyperleukocytosis and leukostasis in acute myeloid leukemia: can a better understanding of the underlying molecular pathophysiology lead to novel treatments?
Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …
Leukapheresis for the management of hyperleukocytosis in acute myeloid leukemia—A systematic review and meta‐analysis
Background Up to 20% of patients with acute myeloid leukemia (AML) present with
hyperleukocytosis, usually defined as a white blood cell (WBC) count greater than 100× …
hyperleukocytosis, usually defined as a white blood cell (WBC) count greater than 100× …
Leukapheresis and hyperleukocytosis, past and future
D Zhang, Y Zhu, Y **, NM Kaweme… - International Journal of …, 2021 - Taylor & Francis
Hyperleukocytosis is a hematologic crisis caused by excessive proliferation of leukemic cells
and has a relatively high early mortality due to a series of severe complications. Therefore …
and has a relatively high early mortality due to a series of severe complications. Therefore …
Endothelial cells: major players in acute myeloid leukaemia
The role of the vascular microenvironment is increasingly studied in acute myeloid
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …
Targeting integrins in drug‐resistant acute myeloid leukaemia
HA Ogana, S Hurwitz, N Wei, E Lee… - British Journal of …, 2024 - Wiley Online Library
Acute myeloid leukaemia (AML) continues to have a poor prognosis, warranting new
therapeutic strategies. The bone marrow (BM) microenvironment consists of niches that …
therapeutic strategies. The bone marrow (BM) microenvironment consists of niches that …
Comparison of early mortality between leukapheresis and non-leukapheresis in adult acute myeloid leukemia patients with hyperleukocytosis: a systematic review …
Objectives One of the treatment modalities that can be used for hyperleukocytosis is
leukapheresis. However, the result of studies showing the benefit of early mortality through …
leukapheresis. However, the result of studies showing the benefit of early mortality through …
Symptomatic Patients with Hyperleukocytic FLT3-ITD Mutated Acute Myeloid Leukemia Might Benefit from Leukapheresis
Simple Summary Leukostasis in hyperleukocytotic acute myeloid leukemia (AML) is a
medical emergency. The optimal treatment strategy and the potential benefits of …
medical emergency. The optimal treatment strategy and the potential benefits of …
Hematology emergencies in adults with critical illness: malignant hematology
J Spring, L Munshi - Chest, 2022 - Elsevier
As outcomes have improved across the hematologic malignancy population, candidacy for
ICU admission has increased. This complex population may develop a variety of …
ICU admission has increased. This complex population may develop a variety of …
What is different in acute hematologic malignancy-associated ARDS? An overview of the literature
Background and Objectives: Acute hematologic malignancies are a group of heterogeneous
blood diseases with a high mortality rate, mostly due to acute respiratory failure (ARF). Acute …
blood diseases with a high mortality rate, mostly due to acute respiratory failure (ARF). Acute …
Post-remission outcomes in AML patients with high hyperleukocytosis and inaugural life-threatening complications
S Fodil, S Chevret, C Rouzaud, S Valade, F Rabian… - PloS one, 2022 - journals.plos.org
Introduction Patients with hyperleukocytic (HL) acute myeloid leukemia (AML) are at higher
risk of early death. Initial management of these patients is challenging, not fully codified and …
risk of early death. Initial management of these patients is challenging, not fully codified and …