The axonal cytoskeleton: from organization to function

JT Kevenaar, CC Hoogenraad - Frontiers in molecular neuroscience, 2015 - frontiersin.org
The axon is the single long fiber that extends from the neuron and transmits electrical
signals away from the cell body. The neuronal cytoskeleton, composed of microtubules …

Much more than a scaffold: cytoskeletal proteins in neurological disorders

DC Muñoz-Lasso, C Romá-Mateo, FV Pallardó… - Cells, 2020 - mdpi.com
Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

Vinculin forms a directionally asymmetric catch bond with F-actin

DL Huang, NA Bax, CD Buckley, WI Weis, AR Dunn - Science, 2017 - science.org
Vinculin is an actin-binding protein thought to reinforce cell-cell and cell-matrix adhesions.
However, how mechanical load affects the vinculin–F-actin bond is unclear. Using a single …

The nano-architecture of the axonal cytoskeleton

C Leterrier, P Dubey, S Roy - Nature Reviews Neuroscience, 2017 - nature.com
The corporeal beauty of the neuronal cytoskeleton has captured the imagination of
generations of scientists. One of the easiest cellular structures to visualize by light …

Dynamic plasma membrane organization: a complex symphony

S van Deventer, AB Arp, AB van Spriel - Trends in Cell Biology, 2021 - cell.com
Membrane protein organization is essential for proper cellular functioning and the result of a
dynamic exchange between protein monomers, nanoscale protein clusters, and microscale …

Actin waves: origin of cell polarization and migration?

N Inagaki, H Katsuno - Trends in cell biology, 2017 - cell.com
Actin filaments and associated proteins undergo wave-like movement in various cell types.
Recent studies with cutting-edge analyses, including live-cell imaging, biophysical …

[HTML][HTML] Neuronal polarization: From spatiotemporal signaling to cytoskeletal dynamics

M Schelski, F Bradke - Molecular and Cellular Neuroscience, 2017 - Elsevier
Neuronal polarization establishes distinct molecular structures to generate a single axon
and multiple dendrites. Studies over the past years indicate that this efficient separation is …

The regulation of actin dynamics during cell division and malignancy

P Gibieža, V Petrikaitė - American journal of cancer research, 2021 - pmc.ncbi.nlm.nih.gov
Actin is the most abundant protein in almost all the eukaryotic cells. Actin amino acid
sequences are highly conserved and have not changed a lot during the progress of …

Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2‐RhoA‐cofilin1 …

J Long, Z Hu, H Xue, Y Wang, J Chen, F Tang… - Cancer …, 2019 - Wiley Online Library
Dendritic cells (DC s) are potent and specialized antigen presenting cells, which play a
crucial role in initiating and amplifying both the innate and adaptive immune responses …

Septins mediate a microtubule–actin crosstalk that enables actin growth on microtubules

K Nakos, MNA Alam, MR Radler, IA Kesisova… - Proceedings of the …, 2022 - pnas.org
Cellular morphogenesis and processes such as cell division and migration require the
coordination of the microtubule and actin cytoskeletons. Microtubule–actin crosstalk is …