The adaptation of natural killer (NK) cells to conditions in the microenvironment of tumors is
deeply affected by their metabolic activity, itself a result of nutrient availability and the …

Due to the unique characteristics of breast cancer initiation sites and significant alterations in
tumor metabolism, breast cancer cells rely on lipid metabolic reprogramming to effectively …

SAP30 is a core subunit of the transcriptional corepressor SIN3 complex, but little is known
about its role in gene regulation and human cancer. Here, we show that SAP30 was a …

In melanoma, predicting which tumors will ultimately metastasize guides treatment
decisions. Transcriptional signatures of primary tumors have been utilized to predict …

The ubiquitin-proteasome system (UPS), which involves E3 ligases and deubiquitinates
(DUBs), is critical for protein homeostasis. The epigenetic reader ZMYND8 (zinc finger …

Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and
plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear …

Abstract Background Junipers (Juniperus spp.) are woody native, invasive plants that have
caused encroachment problems in the US western rangelands, decreasing forage …

Epigenetic mechanisms involving DNA methylation and chromatin modifications have
emerged as critical facilitators of cancer heterogeneity, substantially affecting cancer …

Cholesterol is crucial for cell survival and growth, and dysregulation of cholesterol
homeostasis has been linked to the development of cancer. The tumor microenvironment …

Inhibitors targeting cyclin‐dependent kinases 4 and 6 (CDK4/6) to block cell cycle
progression have been effective in treating hormone receptor‐positive breast cancer, but …