Mucus hypersecretion is a clinical feature of severe respiratory diseases such as asthma,
cystic fibrosis and chronic obstructive pulmonary disease. Airway mucosal infection and/or …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a versatile
and complicated profile, being the fourth most common single cause of death worldwide …

Background Chronic obstructive pulmonary disease (COPD) is characterised by airflow
limitation, and has many components including mucus hypersecretion, oxidative stress, and …

Mucus is a complex polymeric hydrogel that serves as a critical defense in several organs. In
the lungs, it provides a formidable barrier against inhaled particles such as microorganisms …

Melatonin is a pleiotropic biofactor and an effective antioxidant and free radical scavenger
and, as such, can be protective in oxidative stress‐related brain conditions including …

Background: Carbocysteine is a muco-active drug with free radical scavenging and anti-
inflammatory properties. It is actually approved for clinical use as adjunctive therapy of …

Background: Cigarette smoke extract (CSE), a model for studying the effects of tobacco
smoke in vivo and in vitro, induces cell oxidative stress and affects the antioxidative …

It has been shown that mucus hypersecretion is associated with greater susceptibility for
chronic obstructive pulmonary disease (COPD), excess forced expiratory volume in 1 s …

Streptococcus pneumoniae is a major pathogen of respiratory infections that utilizes platelet-
activating factor receptor (PAFR) for firm adherence to host cells. The mucolytic agent S …

Carbocisteine (CCis), a mucoactive agent, is widely used to improve respiratory diseases.
This study demonstrated that CCis increases ciliary bend angle (CBA) by 30% and ciliary …