Effect of exosomal miRNA on cancer biology and clinical applications

Z Sun, K Shi, S Yang, J Liu, Q Zhou, G Wang, J Song… - Molecular cancer, 2018 - Springer
Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely
present in various body fluids. Recently, microRNAs (miRNAs) have been identified in …

MicroRNAs: biomarkers, diagnostics, and therapeutics

W Huang - Bioinformatics in MicroRNA research, 2017 - Springer
MicroRNAs (miRNAs) are small noncoding RNAs (21–23 nucleotides in length) that regulate
gene expression at translational or posttranslational levels. The major regulatory …

Natural killer–derived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms

P Neviani, PM Wise, M Murtadha, CW Liu, CH Wu… - Cancer …, 2019 - aacrjournals.org
In neuroblastoma, the interplay between immune cells of the tumor microenvironment and
cancer cells contributes to immune escape mechanisms and drug resistance. In this study …

Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs

L Min, S Zhu, L Chen, X Liu, R Wei, L Zhao… - Journal of …, 2019 - Taylor & Francis
Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve
patients' survival rate and quality of life. Although the potential role for small extracellular …

Recent trends in targeting miRNAs for cancer therapy

V Shah, J Shah - Journal of Pharmacy and Pharmacology, 2020 - academic.oup.com
Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells
for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the …

MicroRNAs in glioblastoma multiforme pathogenesis and therapeutics

A Shea, V Harish, Z Afzal, J Chijioke, H Kedir… - Cancer …, 2016 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients

K Kleivi Sahlberg, G Bottai, B Naume… - Clinical cancer …, 2015 - aacrjournals.org
Purpose: Triple-negative breast cancers (TNBC) are associated with high risk of early tumor
recurrence and poor outcome. Common prognostic biomarkers give very restricted …

The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells

RC Pink, P Samuel, D Massa, DP Caley, SA Brooks… - Gynecologic …, 2015 - Elsevier
Objective Ovarian cancer is the deadliest gynaecological cancer. A major contributor to the
poor survival rate is the development of chemoresistance to platinum-based therapies such …

[HTML][HTML] The role of exosomal microRNAs in the tumor microenvironment of breast cancer

Q Liu, F Peng, J Chen - International journal of molecular sciences, 2019 - mdpi.com
Breast cancer, ranking first among women's cancers worldwide, develops from the breast
tissue. Study of the breast tissue is, therefore of great significance to the diagnosis and …

Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer

WH Ren, XR Zhang, WB Li, Q Feng… - Cancer management …, 2019 - Taylor & Francis
Background: Myeloid-derived suppressor cells (MDSCs) promote immunosuppression in the
tumor microenvironment, support tumor growth and survival, and may contribute to …