The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Cardiovascular complications remain the leading causes of morbidity and premature
mortality in patients with diabetes mellitus. Studies in humans and preclinical models …

Lamin A, a main constituent of the nuclear lamina, is the major splicing product of the LMNA
gene, which also encodes lamin C, lamin A delta 10 and lamin C2. Involvement of lamin A in …

Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked
to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple …

A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …

Coronary artery disease (CAD) and its major complication, acute myocardial infarction (AMI),
are the leading causes of disability and death worldwide. An individual's risk of develo** …