Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high
morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be …

Curcumin has been shown to have numerous cytotoxic effects on cancer stem cells (CSCs).
This is due to its suppression of the release of cytokines, particularly interleukin (IL)-6, IL-8 …

Hepatocellular carcinoma (HCC) is the most common type of liver malignant tumor, with high
recurrence and mortality rates. Mesenchymal stem cells (MSCs) are multipotent cells that …

Gastrointestinal (GI) cancers with a high global prevalence are a leading cause of morbidity
and mortality. Accordingly, there is a great need to develop efficient therapeutic approaches …

Background: Numerous studies have reported both the tumor-suppressive and oncogenic
roles of the Notch pathway, indicating that Notch activity regulates tumor biology in a …

Curcumin is a dietary polyphenol and a bioactive phytochemical that possesses anti‐
inflammatory, antioxidant, anticancer, and chemopreventive properties, which make it …

In the tumor microenvironment, mesenchymal stromal cells (MSCs) are key modulators of
cancer cell behavior in response to several stimuli. Intratumoral acidosis is a metabolic trait …

It is nowadays widely accepted that some tumors have a niche of cells endowed with
stemness features, which may cause resistance to conventional anticancer therapies and …

Background Accumulating evidences have demonstrated that mesenchymal stem cells
(MSC) could be recruited to the tumor microenvironment. Umbilical cord mesenchymal stem …

Notch signaling plays a key role in a wide variety of human tumors; it can be an oncogene or
a tumor-suppressor gene depending on the tissue context. The functions of Notch1 in …