Alcohol Withdrawal Syndrome (AWS) is characterized as the termination of chronic and
sustained alcohol use that leads to severe symptoms of distress or loss of daily functions …

Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of
various cellular processes. Mitochondrial dysfunctions have been directly linked to …

Ion channels on cytoplasmic membrane function to sense various environmental stimuli. We
here determined the changes of genes encoding ion channels in Caenorhabditis elegans …

A current survey and synthesis of the most important findings in our understanding of the
neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series …

Repeated cycles of intoxication and withdrawal enhance the negative reinforcing properties
of alcohol and lead to neuroadaptations that underlie withdrawal symptoms driving alcohol …

Background Genetic variation contributes to the likelihood that an individual will develop an
alcohol use disorder (AUD). Traditional laboratory studies in animal models have elucidated …

The nematode Caenorhabditis elegans is a valuable model for ecotoxicological research,
yet limited attention has been given to understanding how it absorbs, distributes …

Alcohol abuse and dependence have a substantial heritable component. Although the
genome has been considered the sole vehicle of heritable phenotypes, recent studies …

Chronic excessive ethanol consumption has distinct toxic and adverse effects on a variety of
tissues. In skeletal muscle, ethanol causes alcoholic myopathy, which is characterized by …

Ethanol-induced transcriptional changes underlie important physiological responses to
ethanol that are likely to contribute to the addictive properties of the drug. We examined the …