Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders

S Srivastava, JA Love-Nichols, KA Dies… - Genetics in …, 2019 - nature.com
Abstract Purpose For neurodevelopmental disorders (NDDs), etiological evaluation can be a
diagnostic odyssey involving numerous genetic tests, underscoring the need to develop a …

Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis

A Jourdon, F Wu, J Mariani, D Capauto, S Norton… - Nature …, 2023 - nature.com
Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear
how convergent biological processes in affected individuals may give rise to symptoms …

mTOR signaling disruption and its association with the development of autism spectrum disorder

SD Thomas, NK Jha, S Ojha, B Sadek - Molecules, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by impairments in social interaction and communication along with repetitive stereotypic …

PI3K pathway defects leading to immunodeficiency and immune dysregulation

CJ Nunes-Santos, G Uzel, SD Rosenzweig - Journal of Allergy and Clinical …, 2019 - Elsevier
The phosphatidylinositol 3–kinase (PI3K) signaling pathway is involved in a broad range of
cellular processes, including growth, metabolism, differentiation, proliferation, motility, and …

Neuropsychopathology of autism spectrum disorder: complex interplay of genetic, epigenetic, and environmental factors

R Bhandari, JK Paliwal, A Kuhad - … food intervention and therapy for autism …, 2020 - Springer
Autism spectrum disorder (ASD) is a complex heterogeneous consortium of pervasive
development disorders (PDD) which ranges from atypical autism, autism, and Asperger …

Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy

H Zhuang, Z Liang, G Ma, A Qureshi, X Ran… - MedComm, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The
heterogeneity of ASD poses great challenges for its research and clinical translation. On the …

Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome

BR Yavuz, MK Arici, HC Demirel, CJ Tsai… - NPJ genomic …, 2023 - nature.com
Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs)
are more prone to develop certain types of cancer. Notably, however, the case statistics can …

Malformations of cerebral cortex development: molecules and mechanisms

G Juric-Sekhar, RF Hevner - Annual Review of Pathology …, 2019 - annualreviews.org
Malformations of cortical development encompass heterogeneous groups of structural brain
anomalies associated with complex neurodevelopmental disorders and diverse genetic and …

Protein phosphatase 2A–structure, function and role in neurodevelopmental disorders

P Sandal, CJ Jong, RA Merrill, J Song… - Journal of cell …, 2021 - journals.biologists.com
Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …