Diabetes is a metabolic disease that raises the risk of microvascular and neurological
disorders. Insensitivity to insulin is a characteristic of type II diabetes, which accounts for 85 …

Herein, we describe a stereoselective sulfa-Michael/aldol cyclization reaction promoted by a
rationally designed novel axially chiral styrene-based organocatalyst. A variety of highly …

Protein tyrosine phosphatase 1B (PTP1B) is one of the target enzymes whose disruption
leads to obesity and diabetes. A series of PTP1B inhibitors were isolated from the leaves of …

Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a
considerable impact on human life, long-term health expenditures, and substantial health …

Fermented Capsicum frutescens L. is a well-known traditional food ingredient in China with
a variety of potential nutritional functions due to the increased content of polyphenolic …

Background Oridonin, a diterpenoid lactone derived from medicinal plants, has drawn
considerable attention due to its therapeutic potential, particularly its anticancer properties. It …

Tyrosine protein phosphatase non‐receptor type 1 (PTP1B; also known as protein tyrosine
phosphatase 1B) is a member of the protein tyrosine phosphatase (PTP) family and is a …

We have successfully designed and assembled a 66-member library of protein tyrosine
phosphatases (PTP) inhibitor candidates using α-ketoacid-hydroxylamine (KAHA) ligation …

Less toxicity, wider pharmacological therapeutic window, and greater chemical space have
always inspired phytochemical drug discovery. Continuous advancements in computational …

Type 2 diabetes mellitus (T2DM) is a global problem with increasing prevalence. The current
treatments have made an immense progress with some side effects, such as drug …