Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder
JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …
outcomes in children with a commonality in deficits in social communication and language …
Re-emerging concepts of immune dysregulation in autism spectrum disorders
A Erbescu, SM Papuc, M Budisteanu, A Arghir… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by
communication and social interaction deficits, and by restricted interests and stereotyped …
communication and social interaction deficits, and by restricted interests and stereotyped …
Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control
Background Genetic variants can modulate phenotypic outcomes via epigenetic
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …
Future prospects for epigenetics in autism spectrum disorder
LA Williams, JM LaSalle - Molecular Diagnosis & Therapy, 2022 - Springer
Despite decades of investigation into the genetics of autism spectrum disorder (ASD), a
current consensus in the field persists that ASD risk is too heterogeneous to be diagnosed …
current consensus in the field persists that ASD risk is too heterogeneous to be diagnosed …
Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain
development and socio-cognitive abilities. The pathogenesis of this condition points out the …
development and socio-cognitive abilities. The pathogenesis of this condition points out the …
Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes
Background With the growing availability of cannabis and the popularization of additional
routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use …
routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use …
Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment
Background Gestational exposure to polychlorinated biphenyls (PCBs) has been associated
with elevated risk for neurodevelopmental disorders. Placental epigenetics may serve as a …
with elevated risk for neurodevelopmental disorders. Placental epigenetics may serve as a …
Targeting epigenetic dysregulation in autism spectrum disorders
ML Herrera, J Paraíso-Luna, I Bustos-Martínez… - Trends in Molecular …, 2024 - cell.com
Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies
characterized by deficits in social interaction and repetitive behaviors, collectively affecting …
characterized by deficits in social interaction and repetitive behaviors, collectively affecting …
Early life epigenetics and childhood outcomes: a sco** review
Epigenetics is the study of changes in gene expression, without a change in the DNA
sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation …
sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation …
Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts
Background Prenatal vitamin use is recommended before and during pregnancies for
normal fetal development. Prenatal vitamins do not have a standard formulation, but many …
normal fetal development. Prenatal vitamins do not have a standard formulation, but many …