Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder

JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …

Re-emerging concepts of immune dysregulation in autism spectrum disorders

A Erbescu, SM Papuc, M Budisteanu, A Arghir… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by
communication and social interaction deficits, and by restricted interests and stereotyped …

Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

CJ Gunasekara, H MacKay, CA Scott, S Li, E Laritsky… - Genome biology, 2023 - Springer
Background Genetic variants can modulate phenotypic outcomes via epigenetic
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …

Future prospects for epigenetics in autism spectrum disorder

LA Williams, JM LaSalle - Molecular Diagnosis & Therapy, 2022 - Springer
Despite decades of investigation into the genetics of autism spectrum disorder (ASD), a
current consensus in the field persists that ASD risk is too heterogeneous to be diagnosed …

Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD)

A Ravaei, M Emanuele, G Nazzaro, L Fadiga… - Molecular …, 2023 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain
development and socio-cognitive abilities. The pathogenesis of this condition points out the …

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes

LE Shorey-Kendrick, VHJ Roberts, RJ D'Mello… - Clinical …, 2023 - Springer
Background With the growing availability of cannabis and the popularization of additional
routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use …

Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment

JS Mouat, X Li, K Neier, Y Zhu, CE Mordaunt… - Environmental …, 2023 - Elsevier
Background Gestational exposure to polychlorinated biphenyls (PCBs) has been associated
with elevated risk for neurodevelopmental disorders. Placental epigenetics may serve as a …

Targeting epigenetic dysregulation in autism spectrum disorders

ML Herrera, J Paraíso-Luna, I Bustos-Martínez… - Trends in Molecular …, 2024 - cell.com
Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies
characterized by deficits in social interaction and repetitive behaviors, collectively affecting …

Early life epigenetics and childhood outcomes: a sco** review

S Hari Gopal, T Alenghat, M Pammi - Pediatric Research, 2024 - nature.com
Epigenetics is the study of changes in gene expression, without a change in the DNA
sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation …

Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts

JF Dou, LYM Middleton, Y Zhu, KS Benke… - Epigenetics & …, 2022 - Springer
Background Prenatal vitamin use is recommended before and during pregnancies for
normal fetal development. Prenatal vitamins do not have a standard formulation, but many …