Periodontitis is a complex disease:(a) various causative factors play a role simultaneously
and interact with each other; and (b) the disease is episodic in nature, and bursts of disease …

Epigenetic mechanisms, namely DNA and histone modifications, are critical regulators of
immunity and inflammation which have emerged as potential targets for immunomodulating …

Periodontitis is characterized by irreversible destruction of periodontal tissue. At present, the
accepted etiology of periodontitis is based on a three-factor theory including pathogenic …

Aim The purpose of this study was to investigate the immunomodulatory properties of
periodontal ligament stem cells derived from inflamed periodontal ligament tissues. Material …

Background: Periodontitis is a chronic inflammatory disease involving an interplay between
bacteria, inflammation, host response genes, and environmental factors. The manifestation …

Epigenetics as a modifiable risk factor in periodontal diseases has been investigated in light
of the current knowledge of how chronic infection and inflammation can affect gene‐specific …

The immune response to oral bacteria and the subsequent activation of inflammatory
signaling is not only dependent on genetic factors. The importance of so‐called epigenetic …

Background: Methylation status of the cytokine genes may play a role in the pathogenesis of
inflammatory diseases, such as rheumatoid arthritis (RA) and chronic periodontitis (CP). This …

Periodontitis (PD) is a chronic osteolytic disease that shares pathogenic inflammatory
features with other conditions associated with nonresolving inflammation. A hallmark of PD …

The purpose of the present study was to see if there is a correlation between the effect of
interferons in crevicular fluid and periodontitis, evaluating literature. Interferon gamma (IFN …