Scientific rationale for develo** potent RBD-based vaccines targeting COVID-19

H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …

Whole inactivated virus and protein-based COVID-19 vaccines

PJ Hotez, ME Bottazzi - Annual Review of Medicine, 2022 - annualreviews.org
The rapid development and deployment of mRNA and adenovirus-vectored vaccines
against coronavirus disease 2019 (COVID-19) continue to astound the global scientific …

Challenges and progress towards industrial recombinant protein production in yeasts: a review

P De Brabander, E Uitterhaegen, T Delmulle… - Biotechnology …, 2023 - Elsevier
Recombinant proteins (RP) are widely used as biopharmaceuticals, industrial enzymes, or
sustainable food source. Yeasts, with their ability to produce complex proteins through a …

[HTML][HTML] Evaluation of safety and immunogenicity of receptor-binding domain-based COVID-19 vaccine (Corbevax) to select the optimum formulation in open-label …

S Thuluva, V Paradkar, SR Gunneri, V Yerroju… - …, 2022 - thelancet.com
Background We assessed the efficacy of a receptor-binding domain (RBD)-based protein
subunit COVID-19 vaccine. Methods A randomised Phase-1/2 trial followed by a Phase-2 …

SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T …

J Pollet, WH Chen, L Versteeg, B Keegan… - Human vaccines & …, 2021 - Taylor & Francis
There is an urgent need for an accessible and low-cost COVID-19 vaccine suitable for low-
and middle-income countries. Here, we report on the development of a SARS-CoV-2 …

Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection

J Zang, Y Zhu, Y Zhou, C Gu, Y Yi, S Wang, S Xu, G Hu… - Cell Discovery, 2021 - nature.com
Massive production of efficacious SARS-CoV-2 vaccines is essential for controlling the
ongoing COVID-19 pandemic. We report here the preclinical development of yeast …

From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access

PJ Hotez, R Adhikari, WH Chen, YL Chen… - Expert Review of …, 2023 - Taylor & Francis
Introduction The development of a yeast-expressed recombinant protein-based vaccine
technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine …

Translating diagnostics and drug delivery technologies to low-resource settings

EM Euliano, AA Sklavounos, AR Wheeler… - Science translational …, 2022 - science.org
Diagnostics and drug delivery technologies engineered for low-resource settings aim to
meet their technical design specifications using strategies that are compatible with limited …

[HTML][HTML] Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate

WH Chen, J Pollet, U Strych, J Lee, Z Liu… - Protein Expression and …, 2022 - Elsevier
SARS-CoV-2 protein subunit vaccines are currently being evaluated by multiple
manufacturers to address the global vaccine equity gap, and need for low-cost, easy to …

Immunogenicity and safety of Biological E's CORBEVAX™ vaccine compared to COVISHIELD™(ChAdOx1 nCoV-19) vaccine studied in a phase-3, single blind …

S Thuluva, V Paradkar, SR Gunneri… - Human Vaccines & …, 2023 - Taylor & Francis
Optimum formulation of Biological-E's protein subunit CORBEVAX™ vaccine was selected
in phase-1 and-2 studies and found to be safe and immunogenic in healthy adult population …