Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Cell death by apoptosis and permanent cell cycle arrest by senescence serve as barriers to
the development of cancer. Chemotherapeutic agents not only induce apoptosis, they can …

Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

Skin aging is induced and sustained by chronological aging and photoaging. Aging skin
pigmentation such as mottled pigmentation (senile lentigo) and melasma are typical signs of …

Cellular senescence is a stress response, which can be evoked in all type of somatic cells
by different stimuli. Senescent cells accumulate in the body and participate in aging and …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have
been reported to increase the malignant potency of cancer cells by secreting senescence …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

The accumulation of metabolites in the intervertebral disc is considered an important cause
of intervertebral disc degeneration (IVDD). Lactic acid, which is a metabolite that is produced …

PhosphoInositide-3 Kinase (PI3K) represents a family of different classes of kinases which
control multiple biological processes in mammalian cells, such as cell growth, proliferation …