In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

Pichia pastoris has been recognized as one of the most industrially important hosts for
heterologous protein production. Despite its high protein productivity, the optimization of P …

Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

Highlights•Challenges the biopharmaceutical industry is facing at the moment.•Summary of
data science challenges due to biopharma particularities.•Review of today's data science …

A majority of industrial fermentation processes are operated in fed-batch mode. In this case,
the rate of feed addition to the system is a focus for optimising the process operation, as it …

Monoclonal antibodies (mAbs) and antibody fragments represent the most important
biopharmaceutical products today. Because full length antibodies are glycosylated …

Mechanistic models require a significant investment of time and resources, but their
application to multiple stages of fermentation process development and operation can make …

Soft sensor technique has become a promising solution to enable real-time estimations of
difficult-to-measure quality variables in industrial processes. However, traditional soft sensor …

Cellular agriculture, that is, the cell culture-based production of food, may provide an
alternative to traditional farming, minimizing the environmental effect, while ensuring …

In this paper, a hybrid temperature prediction model is developed for an industrial roller kiln
of lithium-ion battery cathode materials, which is based on first-principle model and moving …