Genetic load: genomic estimates and applications in non-model animals

G Bertorelle, F Raffini, M Bosse, C Bortoluzzi… - Nature Reviews …, 2022 - nature.com
Genetic variation, which is generated by mutation, recombination and gene flow, can reduce
the mean fitness of a population, both now and in the future. This 'genetic load'has been …

Spatiotemporal omics for biology and medicine

L Liu, A Chen, Y Li, J Mulder, H Heyn, X Xu - Cell, 2024 - cell.com
The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

AVONET: morphological, ecological and geographical data for all birds

JA Tobias, C Sheard, AL Pigot, AJM Devenish… - Ecology …, 2022 - Wiley Online Library
Functional traits offer a rich quantitative framework for develo** and testing theories in
evolutionary biology, ecology and ecosystem science. However, the potential of functional …

Integrating gene annotation with orthology inference at scale

BM Kirilenko, C Munegowda, E Osipova, D Jebb… - Science, 2023 - science.org
Annotating coding genes and inferring orthologs are two classical challenges in genomics
and evolutionary biology that have traditionally been approached separately, limiting …

A species-level timeline of mammal evolution integrating phylogenomic data

S Álvarez-Carretero, AU Tamuri, M Battini… - Nature, 2022 - nature.com
High-throughput sequencing projects generate genome-scale sequence data for species-
level phylogenies,–. However, state-of-the-art Bayesian methods for inferring timetrees are …

A comparative genomics multitool for scientific discovery and conservation

Nature, 2020 - nature.com
Abstract The Zoonomia Project is investigating the genomics of shared and specialized traits
in eutherian mammals. Here we provide genome assemblies for 131 species, of which all …

Complexity of avian evolution revealed by family-level genomes

J Stiller, S Feng, AA Chowdhury, I Rivas-González… - Nature, 2024 - nature.com
Despite tremendous efforts in the past decades, relationships among main avian lineages
remain heavily debated without a clear resolution. Discrepancies have been attributed to …

Progressive Cactus is a multiple-genome aligner for the thousand-genome era

J Armstrong, G Hickey, M Diekhans, IT Fiddes… - Nature, 2020 - nature.com
New genome assemblies have been arriving at a rapidly increasing pace, thanks to
decreases in sequencing costs and improvements in third-generation sequencing …

Extreme elevational migration spurred cryptic speciation in giant hummingbirds

JL Williamson, EF Gyllenhaal, SM Bauernfeind… - Proceedings of the …, 2024 - pnas.org
The ecoevolutionary drivers of species niche expansion or contraction are critical for
biodiversity but challenging to infer. Niche expansion may be promoted by local adaptation …

Quality assessment of gene repertoire annotations with OMArk

Y Nevers, A Warwick Vesztrocy, V Rossier… - Nature …, 2025 - nature.com
In the era of biodiversity genomics, it is crucial to ensure that annotations of protein-coding
gene repertoires are accurate. State-of-the-art tools to assess genome annotations measure …