Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human
African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in …

Euglena gracilis, a model organism of the eukaryotic supergroup Discoba harbouring also
clinically important parasitic species, possesses diverse metabolic strategies and an atypical …

New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field are
urgently required. Despite concerted efforts over the last several years, the number of new …

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions of
people in the Americas and across the world, leading to considerable morbidity and …

Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new …

Leishmaniasis is a neglected tropical disease that is estimated to afflict over 12 million
people. Current drugs for leishmaniasis suffer from serious deficiencies, including toxicity …

Introduction Chagas disease (CD) imposes social and economic burdens, yet the available
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …

Highlights•Target deconvolution can enhance pharmaceutical R&D productivity.•A
combination of approaches is usually required for successful target deconvolution.•Target …

Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi that endangers almost 70 million people worldwide. The only two drugs …