Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease

C Barth, A Crestol, AMG de Lange… - The Lancet Diabetes & …, 2023‏ - thelancet.com
Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Cognitive decline in early and premature menopause

M Sochocka, J Karska, M Pszczołowska… - International journal of …, 2023‏ - mdpi.com
Early and premature menopause, or premature ovarian insufficiency (POI), affects 1% of
women under the age of 40 years. This paper reviews the main aspects of early and …

The 2022 hormone therapy position statement of the North American Menopause Society

SS Faubion, CJ Crandall, L Davis… - …, 2022‏ - ingentaconnect.com
“The 2022 Hormone Therapy Position Statement of The North American Menopause
Society”(NAMS) updates “The 2017 Hormone Therapy Position Statement of The North …

Optimising health after early menopause

GD Mishra, MC Davies, S Hillman, HF Chung, S Roy… - The Lancet, 2024‏ - thelancet.com
The typical age at menopause is 50–51 years in high-income countries. However, early
menopause is common, with around 8% of women in high-income countries and 12% of …

Reproductive factors and the risk of incident dementia: a cohort study of UK Biobank participants

J Gong, K Harris, SAE Peters, M Woodward - PLoS medicine, 2022‏ - journals.plos.org
Background Women's reproductive factors have been associated with the risk of dementia;
however, these findings remain uncertain. This study aimed to examine the risk of incident …

Menopause and cognitive impairment: a narrative review of current knowledge

DM Conde, RC Verdade… - World journal of …, 2021‏ - pmc.ncbi.nlm.nih.gov
A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment
represents a transition between normal cognition and dementia. The frequency of cognitive …

Brain fog in menopause: a health-care professional's guide for decision-making and counseling on cognition

PM Maki, NG Jaff - Climacteric, 2022‏ - Taylor & Francis
Midlife women commonly experience changes in their cognitive function as they transition
through menopause and express concern about whether these changes represent the initial …

[HTML][HTML] Estrogen plays an important role by influencing the NLRP3 inflammasome

W Dong, Q Peng, Z Liu, Z **e, X Guo, Y Li… - Biomedicine & …, 2023‏ - Elsevier
The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is an important part of the natural immune system that plays an important role …

The influence of the gut microbiome on ovarian aging

F Huang, Y Cao, J Liang, R Tang, S Wu, P Zhang… - Gut …, 2024‏ - Taylor & Francis
Ovarian aging occurs prior to the aging of other organ systems and acts as the pacemaker of
the aging process of multiple organs. As life expectancy has increased, preventing ovarian …

FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

J **ong, SS Kang, M Wang, Z Wang, Y **a… - Nature …, 2023‏ - nature.com
Alzheimer's disease (AD) is the most common dementia. It is known that women with one
ApoE4 allele display greater risk and earlier onset of AD compared with men. In mice, we …