Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …

Focal adhesion kinase (FAK) relays integrin signaling from outside to inside cells and
contributes to cell adhesion and motility. However, the spatiotemporal dynamics of FAK …

Platelets interact with the coagulation system in a multitude of ways, not only during the
phases of thrombus formation, but also in specific areas within a formed thrombus. This …

Despite the vital role of mechanical forces in biology, it still remains a challenge to image
cellular force with sub-100-nm resolution. Here, we present tension points accumulation for …

Integrins link the extracellular environment to the actin cytoskeleton in cell migration and
adhesiveness. Rapid coordination between events outside and inside the cell is essential …

T cells defend against cancer and viral infections by rapidly scanning the surface of target
cells seeking specific peptide antigens. This key process in adaptive immunity is sparked …

In the last decade, DNA-based tension sensors have made significant contributions to the
study of the importance of mechanical forces in many biological systems. Albeit successful …

Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …

The advent of molecular tension probes for real-time map** of piconewton forces in living
systems has had a major impact on mechanobiology. For example, DNA-based tension …