Recent advances in single molecule experiments have raised many challenges. These
challenges can be met by a proper understanding of the inter-and intra-molecular …

As a key molecule of life, Deoxyribo-Nucleic Acid (DNA) is the focus of numbers of
investigations with the help of biological, chemical and physical techniques. From a physical …

Cells transmit piconewton forces to receptors to mediate processes such as migration and
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …

The rupture of double-stranded DNA under stress is a key process in biophysics and
nanotechnology. In this article, we consider the shear-induced rupture of short DNA …

We present a miniature centrifuge force microscope (CFM) that repurposes a benchtop
centrifuge for high-throughput single-molecule experiments with high-resolution particle …

Polymer chains that interact with themselves and/or with their environment are fascinating
objects, displaying a range of interesting physical and chemical phenomena. The focus in …

MesoBioNano (MBN) Explorer is a multi-purpose software package for advanced multiscale
simulations of complex molecular structure and dynamics. It has many unique features and a …

We investigate the dynamics of polymer translocation through a nanopore under an
externally applied field using the two-dimensional fluctuating bond model with single …

Despite the inherently quantum mechanical nature of hydrogen bonding, it is unclear how
nuclear quantum effects (NQEs) alter the strengths of hydrogen bonds. With this in mind, we …

Methyl-cytosine (5mC) is one of the most important DNA modifications and plays versatile
biological roles. It is well known that 5mC stabilizes DNA duplexes. However, it remains …