Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide, an endogenous stimulator of mitochondrial function in cancer cells

C Szabo - Cells, 2021 - mdpi.com
Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition
of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its …

[HTML][HTML] Evolving CAR-T-cell therapy for cancer treatment: from scientific discovery to cures

A Majumder - Cancers, 2023 - mdpi.com
Simple Summary It is well recognized now that the development of drug resistance is one of
the leading causes of treatment failure in conventional therapies. In comparison, recent …

[HTML][HTML] Targeting homocysteine and hydrogen sulfide balance as future therapeutics in cancer treatment

A Majumder - Antioxidants, 2023 - mdpi.com
A high level of homocysteine (Hcy) is associated with oxidative/ER stress, apoptosis, and
impairment of angiogenesis, whereas hydrogen sulfide (H2S) has been found to reverse this …

[HTML][HTML] HER3: toward the prognostic significance, therapeutic potential, current challenges, and future therapeutics in different types of cancer

A Majumder - Cells, 2023 - mdpi.com
Human epidermal growth factor receptor 3 (HER3) is the only family member of the
EGRF/HER family of receptor tyrosine kinases that lacks an active kinase domain (KD) …

Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production

N Song, X Li, Y Cui, T Zhang, S Xu, S Li - Journal of hazardous materials, 2021 - Elsevier
Hydrogen sulfide (H 2 S) is an air pollutant to cause tracheal injury. Pyroptosis is
responsible for tissue injury through reactive oxygen species (ROS) production. Competitive …

Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation

Y Wang, R Yu, L Wu, G Yang - Cellular signalling, 2021 - Elsevier
Recognized as a novel and important gasotransmitter, hydrogen sulfide (H 2 S) is widely
present in various tissues and organs. Cystathionine gamma-lyase (CSE)-derived H 2 S has …

Hydrogen sulfide signaling in regulation of cell behaviors

Y Wang, R Yu, L Wu, G Yang - Nitric Oxide, 2020 - Elsevier
Recent advances in the biomedical importance of H 2 S have help us understand various
cellular functions and pathophysiological processes from a new aspect. Specially, H 2 S has …

[HTML][HTML] High-dose vitamin B6 (pyridoxine) displays strong anti-inflammatory properties in lipopolysaccharide-stimulated monocytes

K Mikkelsen, N Dargahi, S Fraser, V Apostolopoulos - Biomedicines, 2023 - mdpi.com
Vitamin B6 is shown to have anti-inflammatory properties, which makes it an interesting
nutraceutical agent. Vitamin B6 deficiency is well established as a contributor to …

Dietary supplementation of octacosanol improves exercise-induced fatigue and its molecular mechanism

Y Zhou, F Cao, Q Wu, Y Luo, T Guo, S Han… - Journal of Agricultural …, 2021 - ACS Publications
Several publications report that octacosanol (OCT) has different biological functions. This
study was designed to evaluate the antifatigue effect and molecular mechanism of …