Human topoisomerases and their roles in genome stability and organization
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
Endogenous DNA damage as a source of genomic instability in cancer
A Tubbs, A Nussenzweig - Cell, 2017 - cell.com
Genome instability, defined as higher than normal rates of mutation, is a double-edged
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
β-Glucan reverses the epigenetic state of LPS-induced immunological tolerance
Innate immune memory is the phenomenon whereby innate immune cells such as
monocytes or macrophages undergo functional reprogramming after exposure to microbial …
monocytes or macrophages undergo functional reprogramming after exposure to microbial …
Epigenetic regulation of the innate immune response to infection
Q Zhang, X Cao - Nature Reviews Immunology, 2019 - nature.com
Innate immune cells have complex signalling pathways for sensing pathogens and initiating
innate immune responses against infection. These pathways are tightly regulated at different …
innate immune responses against infection. These pathways are tightly regulated at different …
Comparative flavivirus-host protein interaction map** reveals mechanisms of dengue and Zika virus pathogenesis
Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …
Disease tolerance and immunity in host protection against infection
The immune system probably evolved to limit the negative effects exerted by pathogens on
host homeostasis. This defence strategy relies on the concerted action of innate and …
host homeostasis. This defence strategy relies on the concerted action of innate and …
The pro-tumorigenic host response to cancer therapies
Y Shaked - Nature Reviews Cancer, 2019 - nature.com
Resistance to cancer therapy remains a major challenge in clinical oncology. Although the
initial treatment phase is often successful, eventual resistance, characterized by tumour …
initial treatment phase is often successful, eventual resistance, characterized by tumour …
DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity
Y Kitai, T Kawasaki, T Sueyoshi… - The Journal of …, 2017 - journals.aai.org
Danger-associated molecular patterns derived from damaged or dying cells elicit
inflammation and potentiate antitumor immune responses. In this article, we show that …
inflammation and potentiate antitumor immune responses. In this article, we show that …
Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis
R Wu, J Liu, N Wang, L Zeng, C Yu, F Chen… - Science translational …, 2022 - science.org
Sepsis is a challenging clinical syndrome caused by a dysregulated host response to
infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 …
infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 …