Advances in tenascin-C biology
KS Midwood, T Hussenet, B Langlois… - Cellular and molecular life …, 2011 - Springer
Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently
expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different …
expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different …
The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma
AE Sirica - Nature reviews Gastroenterology & hepatology, 2012 - nature.com
Intrahepatic cholangiocarcinoma is typically characterized by a dense desmoplastic stroma,
of which cancer-associated myofibroblasts (which express α-smooth muscle actin), are a …
of which cancer-associated myofibroblasts (which express α-smooth muscle actin), are a …
[PDF][PDF] Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth
In addition to soluble factors, the extracellular matrix (ECM) also plays a vital role in normal
vasculogenesis and in the pathological angiogenesis of many disease states. Here we will …
vasculogenesis and in the pathological angiogenesis of many disease states. Here we will …
Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma
Epithelial cancers (carcinoma) account for 80%–90% of all cancers. The development of
carcinoma is associated with disrupted epithelial organization and solid ductal structures …
carcinoma is associated with disrupted epithelial organization and solid ductal structures …
Microsomal Prostaglandin E2 Synthase-1 Modulates the Response to Vascular Injury
M Wang, K Ihida-Stansbury, D Kothapalli, MC Tamby… - Circulation, 2011 - Am Heart Assoc
Background—Microsomal (m) prostaglandin (PG) E2 synthase (S)-1 catalyzes the formation
of PGE2 from PGH2, a cyclooxygenase product that is derived from arachidonic acid …
of PGE2 from PGH2, a cyclooxygenase product that is derived from arachidonic acid …
Tenascin-C: Exploitation and collateral damage in cancer management
C Spenlé, F Saupe, K Midwood, H Burckel… - Cell adhesion & …, 2015 - Taylor & Francis
Despite an increasing knowledge about the causes of cancer, this disease is difficult to cure
and still causes far too high a death rate. Based on advances in our understanding of …
and still causes far too high a death rate. Based on advances in our understanding of …
The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation
Breast cancer is the most commonly diagnosed malignancy in women. Analysis of breast
cancer genomic DNA indicates frequent loss-of-function mutations in components of the …
cancer genomic DNA indicates frequent loss-of-function mutations in components of the …
Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma
AE Sirica, DJ Campbell, CI Dumur - Current opinion in …, 2011 - journals.lww.com
Increasing our understanding of critical interactive pathways by which cancer-associated
fibroblastic cells crosstalk with cholangiocarcinoma cells to promote tumor progression can …
fibroblastic cells crosstalk with cholangiocarcinoma cells to promote tumor progression can …
Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages
Extracellular matrix (ECM) has been focused to understand tumor progression in addition to
the genetic mutation of cancer cells. Here, we prepared “staged tumorigenesis-mimicking …
the genetic mutation of cancer cells. Here, we prepared “staged tumorigenesis-mimicking …
[PDF][PDF] Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland
Breast cancer patients diagnosed postpartum have poor prognosis. The postpartum
mammary gland undergoes tissue regression to return to the pre-pregnant state. This …
mammary gland undergoes tissue regression to return to the pre-pregnant state. This …