This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Despite advances in understanding the development and progression of cancer in recent
years, there remains a lack of comprehensive characterization of the cancer glycoproteome …

Highlights•Simulations provide a computational tool to probe membrane structure and
dynamics.•Simulations can successfully predict lipid binding sites on membrane …

Large-scale conformational changes are essential to link protein structures with their
function at the cell and organism scale, but have been elusive both experimentally and …

Lipid molecules are able to selectively interact with specific sites on integral membrane
proteins, and modulate their structure and function. Identification and characterization of …

Glucose homeostasis and growth essentially depend on the hormone insulin engaging its
receptor. Despite biochemical and structural advances, a fundamental contradiction has …

Glycosylation changes are key molecular events in tumorigenesis, progression and
glycosyltransferases play a vital role in the this process. FUT8 belongs to the …