Inherently defective immunity typically results in either ineffective host defense, immune
regulation, or both. As a category of primary immunodeficiency diseases, those that impair …

Unbiased genetic studies have uncovered surprising molecular mechanisms in human
cellular immunity and autoimmunity. We performed whole-exome sequencing and targeted …

Normal cellular function is dependent on a number of highly regulated homeostatic
mechanisms, which act in concert to maintain conditions suitable for life. During periods of …

Background Coat protein complex 1 (COPI) is integral in the sorting and retrograde
trafficking of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum (ER) …

Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in
autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis …

Background Oral squamous cell carcinoma (OSCC) is a main cause of oral cancer mortality
and morbidity in central south Asia. To improve the clinical outcome of OSCC patients …

Primary microcephaly is a congenital brain malformation characterized by a head
circumference less than three standard deviations below the mean for age and sex and …

Coat protein complex I (COPI) is best known for its role in Golgi-endoplasmic reticulum (ER)
trafficking, responsible for the retrograde transport of ER-resident proteins. The ER is crucial …

Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) regulates cell and whole-
body metabolism and supports tumorigenesis. The cellular impacts of perturbing CAMKK2 …

Colorectal cancer is considered as the third leading cause of cancer death. In the present
study, we investigated the potential anticancer effect and the molecular mechanism of …