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The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour
Neuropeptide Y (NPY), one of the most abundant peptides in the nervous system, exerts its
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …
[HTML][HTML] From bench to bedside: implications of lipid nanoparticle carrier reactogenicity for advancing nucleic acid therapeutics
In biomedical applications, nanomaterial-based delivery vehicles, such as lipid
nanoparticles, have emerged as promising instruments for improving the solubility, stability …
nanoparticles, have emerged as promising instruments for improving the solubility, stability …
Vitiligo, from physiopathology to emerging treatments: a review
Vitiligo is a chronic inflammatory skin disease leading to the loss of epidermal melanocytes.
To date, treatment options for vitiligo patients are limited, lack sustained efficacy, and are …
To date, treatment options for vitiligo patients are limited, lack sustained efficacy, and are …
[HTML][HTML] Role of cytokines in vitiligo: pathogenesis and possible targets for old and new treatments
P Custurone, L Di Bartolomeo, N Irrera… - International journal of …, 2021 - mdpi.com
Vitiligo is a chronic autoimmune dermatosis of which the pathogenesis remains scarcely
known. A wide variety of clinical studies have been proposed to investigate the immune …
known. A wide variety of clinical studies have been proposed to investigate the immune …
Meta‐Analysis of Alterations in Regulatory T Cells' Frequency and Suppressive Capacity in Patients with Vitiligo
Vitiligo is a noncontagious autoimmune skin depigmenting disease. Regulatory T cells
(Tregs) play a key role in maintaining peripheral tolerance; however, Tregs' number …
(Tregs) play a key role in maintaining peripheral tolerance; however, Tregs' number …
Activated NLR family pyrin domain containing 3 (NLRP3) inflammasome in keratinocytes promotes cutaneous T-cell response in patients with vitiligo
Background Keratinocytes can function as innate immune cells under oxidative stress and
aggravate the cutaneous T-cell response that undermines melanocytes in the setting of …
aggravate the cutaneous T-cell response that undermines melanocytes in the setting of …
IL‐17 induces cellular stress microenvironment of melanocytes to promote autophagic cell apoptosis in vitiligo
J Zhou, X An, J Dong, Y Wang, H Zhong… - The FASEB …, 2018 - Wiley Online Library
Vitiligo is a depigmentary disorder that develops as a result of the progressive
disappearance of epidermal melanocytes. Stress can precipitate or exacerbate a skin …
disappearance of epidermal melanocytes. Stress can precipitate or exacerbate a skin …
Biomarkers of disease activity in vitiligo: A systematic review
R Speeckaert, M Speeckaert, S De Schepper… - Autoimmunity …, 2017 - Elsevier
The pathophysiology of vitiligo is complex although recent research has discovered several
markers which are linked to vitiligo and associated with disease activity. Besides providing …
markers which are linked to vitiligo and associated with disease activity. Besides providing …
[HTML][HTML] Pomegranate extract (POMx) induces mitochondrial dysfunction and apoptosis of oral cancer cells
The anticancer effect of pomegranate polyphenolic extract POMx in oral cancer cells has
rarely been explored, especially where its impact on mitochondrial functioning is concerned …
rarely been explored, especially where its impact on mitochondrial functioning is concerned …
Tumor Necrosis Factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo
Tumor necrosis factor-α (TNF-α) is a major mediator of inflammation and its increased levels
have been analyzed in vitiligo patients. Vitiligo is a depigmentary skin disarray caused due …
have been analyzed in vitiligo patients. Vitiligo is a depigmentary skin disarray caused due …