One of the most challenging areas of pharmaceutical research is ocular drug delivery. The
unique anatomy and physiology of the eye impedes drug permeation to deeper ocular …

Introduction: Considering that the number of patients afflicted by posterior eye diseases is
increasing, effective drug delivery is currently in high clinical demand. Topical administration …

Drug delivery to the back of the eye following topical administration remains an unmet need
for the scientific community. Treatment of posterior segment diseases requires localized and …

Eye drops are the most common and convenient route of topical administration and the first
choice of treatment for many ocular diseases. However, the ocular bioavailability of …

Distribution of drugs into tissues is an important determinant of the overall PK and PD profile.
Thus, bioanalysis of drugs and their metabolites in tissues can play an important role in …

A simple, fast, and responsive liquid chromatography‐tandem mass spectrometry method
was established and fully validated according to the United States Food and Drug …

Abstract Development and characterization of dexamethasone (DEX)-encapsulated
polymeric nanomicelles have been reported. A low molecular weight di-block copolymer …

Purpose The primary objective of this study were to optimize aqueous micellar solution of
isopropyl ester prodrug of resolvin (RX-10045), study in vivo ocular compatibility and tissue …

Novel monolithic capillary columns with embedded graphene were developed and used for
polymer monolith microextraction (PMME) coupled to LC–MS analysis. The column was …

Glucocorticoids are widely used as highly effective drugs for treating inflammatory diseases.
In this study, a method was developed and validated using liquid chromatography-tandem …