Pathogenesis of NEC: impact of an altered intestinal microbiome

J Neu, M Pammi - Seminars in perinatology, 2017 - Elsevier
Necrotizing enterocolitis (NEC), a disease most commonly seen in preterm infants, often
presents without warning and is associated with very high mortality and morbidity. Progress …

Pathogenesis of NEC: Role of the innate and adaptive immune response

TL Denning, AM Bhatia, AF Kane, RM Patel… - Seminars in …, 2017 - Elsevier
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants with high case
fatality and significant morbidity among survivors. Immaturity of intestinal host defenses …

Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease

CJ Stewart, ND Embleton, ECL Marrs, DP Smith… - Microbiome, 2016 - Springer
Background The preterm microbiome is crucial to gut health and may contribute to
necrotising enterocolitis (NEC), which represents the most significant pathology affecting …

An exclusively human milk diet reduces necrotizing enterocolitis

K Herrmann, K Carroll - Breastfeeding Medicine, 2014 - liebertpub.com
Objective: This study tested the hypothesis that feeding an exclusively human milk (EHM)
diet to premature infants reduces the incidence of necrotizing enterocolitis (NEC) associated …

[HTML][HTML] A novel role for necroptosis in the pathogenesis of necrotizing enterocolitis

AD Werts, WB Fulton, MR Ladd, A Saad-Eldin… - Cellular and molecular …, 2020 - Elsevier
Background & Aims Necrotizing enterocolitis (NEC) is a devastating disease of premature
infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and …

Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics

E Agakidou, C Agakidis, H Gika, K Sarafidis - Frontiers in Pediatrics, 2020 - frontiersin.org
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …

Necrotizing enterocolitis and the preterm infant microbiome

JR Baranowski, EC Claud - … and Child Gastrointestinal Health: Advances in …, 2019 - Springer
Bacterial colonization patterns in preterm infants differ from those of their term counterparts
due to maternal microbial diversity, delivery mode, feeding methods, antibiotic use, and …

Neurodevelopmental outcome of infants who develop necrotizing enterocolitis: The gut-brain axis

J Lu, CR Martin, EC Claud - Seminars in perinatology, 2023 - Elsevier
Necrotizing enterocolitis (NEC) poses a significant risk for neurodevelopmental impairment
in extremely preterm infants. The gut microbiota shapes the development of the gut, immune …

A critical question for NEC researchers: can we create a consensus definition of NEC that facilitates research progress?

PV Gordon, JR Swanson, BC MacQueen… - Seminars in …, 2017 - Elsevier
In the last decades the reported incidence of preterm necrotizing enterocolitis (NEC) has
been declining in large part due to implementing comprehensive NEC prevention initiatives …

Changing the paradigm of defining, detecting, and diagnosing NEC: Perspectives on Bell's stages and biomarkers for NEC

SM Gephart, PV Gordon, AH Penn, KE Gregory… - Seminars in pediatric …, 2018 - Elsevier
Better means to diagnose and define necrotizing enterocolitis are needed to guide clinical
practice and research. Adequacy of Bell's staging system for clinical practice and clarity of …