Runs of homozygosity: windows into population history and trait architecture

FC Ceballos, PK Joshi, DW Clark, M Ramsay… - Nature Reviews …, 2018 - nature.com
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each
parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding …

Runs of homozygosity: current knowledge and applications in livestock

E Peripolli, DP Munari, M Silva, ALF Lima… - Animal …, 2017 - Wiley Online Library
This review presents a broader approach to the implementation and study of runs of
homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH …

High-depth African genomes inform human migration and health

A Choudhury, S Aron, LR Botigué, D Sengupta… - Nature, 2020 - nature.com
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

Inbreeding depression explains killer whale population dynamics

M Kardos, Y Zhang, KM Parsons, H Kang… - Nature Ecology & …, 2023 - nature.com
Understanding the factors that cause endangered populations to either grow or decline is
crucial for preserving biodiversity. Conservation efforts often address extrinsic threats, such …

Population genomics of the critically endangered kākāpō

N Dussex, T Van Der Valk, HE Morales, CW Wheat… - Cell Genomics, 2021 - cell.com
The kākāpō is a flightless parrot endemic to New Zealand. Once common in the archipelago,
only 201 individuals remain today, most of them descending from an isolated island …

Ancient gene flow from early modern humans into Eastern Neanderthals

M Kuhlwilm, I Gronau, MJ Hubisz, C De Filippo… - Nature, 2016 - nature.com
It has been shown that Neanderthals contributed genetically to modern humans outside
Africa 47,000–65,000 years ago. Here we analyse the genomes of a Neanderthal and a …

Early farmers from across Europe directly descended from Neolithic Aegeans

Z Hofmanová, S Kreutzer… - Proceedings of the …, 2016 - National Acad Sciences
Farming and sedentism first appeared in southwestern Asia during the early Holocene and
later spread to neighboring regions, including Europe, along multiple dispersal routes …

Genome flux and stasis in a five millennium transect of European prehistory

C Gamba, ER Jones, MD Teasdale… - Nature …, 2014 - nature.com
Abstract The Great Hungarian Plain was a crossroads of cultural transformations that have
shaped European prehistory. Here we analyse a 5,000-year transect of human genomes …

Upper Palaeolithic genomes reveal deep roots of modern Eurasians

ER Jones, G Gonzalez-Fortes, S Connell… - Nature …, 2015 - nature.com
We extend the scope of European palaeogenomics by sequencing the genomes of Late
Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old …

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

A Tin, J Marten, VL Halperin Kuhns, Y Li, M Wuttke… - Nature …, 2019 - nature.com
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …