The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Highlights•Structure-based mechanisms are available for five major classes of multi-drug
transporters.•Three transporter classes form tripartite assemblies spanning the bacterial cell …

Gram-positive organisms are responsible for some of the most serious of human infections.
Resistance to front-line antimicrobial agents can complicate otherwise curative therapy …

The microorganism resistance to antibiotics has become one of the most worrying issues for
science due to the difficulties related to clinical treatment and the rapid spread of diseases …

Translocator protein 18 kDa (TSPO) was previously known as the peripheral
benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the …

The insertion and assembly of proteins into the inner membrane of bacteria are crucial for
many cellular processes, including cellular respiration, signal transduction, and ion and pH …

Bacterial resistance to biocides used as antiseptics, dyes, and disinfectants is a growing
concern in food preparation, agricultural, consumer manufacturing, and health care …

Tripartite ATP-independent periplasmic (TRAP) transporters are secondary-active
transporters that receive their substrates via a soluble-binding protein to move bioorganic …