Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

Deexcitation During Fibrillation Induction and Defibrillation. Previous models of fibrillation
induction and defibrillation stressed the contribution of depolarization during the response of …

Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy, 4th Edition, by Drs.
Kenneth A. Ellenbogen, Bruce L. Wilkoff, G. Neal Kay, and Chu-Pak Lau, helps you deliver …

Delivery of a strong electric shock to the heart remains the only effective therapy against
ventricular fibrillation. Despite significant improvements in implantable cardioverter …

Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia and often involves
reentrant electrical activation (eg spiral waves). Drug therapy for AF can have serious side …

Electric shock is the only effective therapy against ventricular fibrillation. However, shocks
are also known to cause electroporation of cell membranes. We sought to determine the …

Background—Matrix metalloproteinases (MMPs) contribute to left ventricular remodeling
after myocardial infarction (MI). Specific causative roles of particular MMPs, however, remain …

Defibrillation shocks are commonly used to terminate life-threatening arrhythmias. According
to the excitation theory of defibrillation, such shocks are aimed at depolarizing the …

Background—Previously, we have shown that a premature stimulus can significantly
modulate spatial gradients of ventricular repolarization (ie, modulated dispersion), which …

Unlike other excitation-contraction uncouplers, blebbistatin has few electrophysiological
side effects and has gained increasing acceptance as an excitation-contraction uncoupler in …