Globally with over 10 million deaths per year, cancer is the most transversal disease across
countries, cultures, and ethnicities, affecting both developed and develo** regions …

In this study, we provide a systems biology method to investigate the carcinogenic
mechanism of oral squamous cell carcinoma (OSCC) in order to identify some important …

Psoriasis is a chronic skin disease that affects millions of people worldwide. In 2014,
psoriasis was recognized by the World Health Organization (WHO) as a serious non …

Factor analysis, ranging from principal component analysis to nonnegative matrix
factorization, represents a foremost approach in analyzing multi-dimensional data to extract …

Accurate inference of gene regulatory networks (GRN) is an essential component of systems
biology, and there is a constant development of new inference methods. The most common …

Bladder cancer is the 10th most common cancer worldwide. Due to the lack of
understanding of the oncogenic mechanisms between muscle-invasive bladder cancer …

The gene regulatory network (GRN) of a cell executes genetic programs in response to
environmental and internal cues. Two distinct classes of methods are used to infer …

TP53, the Guardian of the Genome, is the most frequently mutated gene in human cancers
and the functional characterization of its regulation is fundamental. To address this we …

The coronavirus disease 2019 (COVID-19) epidemic is currently raging around the world at
a rapid speed. Among COVID-19 patients, SARS-CoV-2-associated acute respiratory …

Motivation Computational modeling of cell state transitions has been a great interest of many
in the field of developmental biology, cancer biology, and cell fate engineering because it …