Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

Cardiovascular disease (CVD) is the leading cause of death in the United States and aging
is a major risk factor for CVD development. One of the major age-related arterial phenotypes …

Metformin, as the basic pharmacological therapy and the first preventive drug in type 2
diabetes mellitus (T2DM), is proved to have potential protection in diabetic kidney disease …

During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …

The transcription factors that regulate endothelial cell development have been a focus of
active research for several years, and many players in the endothelial transcriptional …

Apoptosis occurs frequently in myocardial infarction, oxidative stress injury, and
ischemia/reperfusion injury, and plays a pivotal role in the development of heart diseases …

Background and Purpose Endothelial dysfunction can be detected at an early stage in the
development of diabetes‐related microvascular disease and is associated with accelerated …

Abstract Nicotinamide N-methyltransferase (NNMT, EC 2.1. 1.1.) plays an important role in
the growth of many different tumours and is also involved in various non-neoplastic …

The establishment and maintenance of the vascular system is critical for embryonic
development and postnatal life. Defects in endothelial cell development and vessel …

The Forkhead family of transcription factors mediates many aspects of physiology, including
stress response, metabolism, commitment to apoptosis, and development. The Forkhead …