Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - Signal transduction and …, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Bidirectional microglia–neuron communication in health and disease

Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

M Maitra, H Mitsuhashi, R Rahimian, A Chawla… - Nature …, 2023 - nature.com
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …

The S100B story: from biomarker to active factor in neural injury

F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …

Brain‐derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection

C Phillips - Neural plasticity, 2017 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Serotonin and neuroplasticity–links between molecular, functional and structural pathophysiology in depression

C Kraus, E Castrén, S Kasper… - … & Biobehavioral Reviews, 2017 - Elsevier
Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

Psychedelics and other psychoplastogens for treating mental illness

MV Vargas, R Meyer, AA Avanes, M Rus… - Frontiers in …, 2021 - frontiersin.org
Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …

Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder

SF Husain, R Yu, TB Tang, WW Tam, B Tran… - Scientific reports, 2020 - nature.com
Reduced haemodynamic response in the frontotemporal cortices of patients with major
depressive disorder (MDD) has been demonstrated using functional near-infrared …

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

MJF Levy, F Boulle, HW Steinbusch… - …, 2018 - Springer
Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

[HTML][HTML] Major depression: one brain, one disease, one set of intertwined processes

EV Filatova, MI Shadrina, PA Slominsky - Cells, 2021 - mdpi.com
Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …