Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Fibrosis represents the common end stage of chronic organ injury independent of the initial
insult, destroying tissue architecture and driving organ failure. Here we discover a …

Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …