Effects of stress throughout the lifespan on the brain, behaviour and cognition

SJ Lupien, BS McEwen, MR Gunnar… - Nature reviews …, 2009 - nature.com
Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy,
childhood, adolescence, adulthood or aging, has an impact on brain structures involved in …

Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex

BS McEwen, C Nasca, JD Gray - Neuropsychopharmacology, 2016 - nature.com
The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …

Physiology and neurobiology of stress and adaptation: central role of the brain

BS McEwen - Physiological reviews, 2007 - journals.physiology.org
The brain is the key organ of the response to stress because it determines what is
threatening and, therefore, potentially stressful, as well as the physiological and behavioral …

Stress and the brain: from adaptation to disease

ER De Kloet, M Joëls, F Holsboer - Nature reviews neuroscience, 2005 - nature.com
In response to stress, the brain activates several neuropeptide-secreting systems. This
eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed …

Adverse childhood experiences, allostasis, allostatic load, and age-related disease

A Danese, BS McEwen - Physiology & behavior, 2012 - Elsevier
How do adverse childhood experiences get 'under the skin'and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …

[HTML][HTML] Uncertainty and stress: Why it causes diseases and how it is mastered by the brain

A Peters, BS McEwen, K Friston - Progress in neurobiology, 2017 - Elsevier
The term 'stress'–coined in 1936–has many definitions, but until now has lacked a
theoretical foundation. Here we present an information-theoretic approach–based on the …

The neurobiology of stress: from serendipity to clinical relevance

BS McEwen - Brain research, 2000 - Elsevier
The hormones and other physiological agents that mediate the effects of stress on the body
have protective and adaptive effects in the short run and yet can accelerate pathophysiology …

Protective and damaging effects of mediators of stress: elaborating and testing the concepts of allostasis and allostatic load

BS McEwen, T Seeman - Annals of the New York Academy of …, 1999 - Wiley Online Library
Stress is a condition of human existence and a factor in the expression of disease. A broader
view of stress is that it is not just the dramatic stressful events that exact their toll but rather …

Allostasis and allostatic load: implications for neuropsychopharmacology

BS McEwen - Stress and the Brain, 2013 - taylorfrancis.com
The primary hormonal mediators of the stress response, glucocorticoids and
catecholamines, have both protective and damaging effects on the body. In the short run …

The corticosteroid receptor hypothesis of depression

F Holsboer - Neuropsychopharmacology, 2000 - Elsevier
Signs and symptoms that are characteristic for depression include changes in the setpoint of
the hypothalamic-pituitary-adrenocortical (HPA) system, which in the majority of these …