Lipid droplets and lipid mediators in viral infection and immunity
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …
The dynamic roles of intracellular lipid droplets: from archaea to mammals
DJ Murphy - Protoplasma, 2012 - Springer
During the past decade, there has been a paradigm shift in our understanding of the roles of
intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have …
intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have …
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …
ESX‐1‐mediated translocation to the cytosol controls virulence of mycobacteria
D Houben, C Demangel, J Van Ingen… - Cellular …, 2012 - Wiley Online Library
Mycobacterium species, including Mycobacterium tuberculosis and Mycobacterium leprae,
are among the most potent human bacterial pathogens. The discovery of cytosolic …
are among the most potent human bacterial pathogens. The discovery of cytosolic …
The lipid droplet—a well-connected organelle
Q Gao, JM Goodman - Frontiers in cell and developmental biology, 2015 - frontiersin.org
Our knowledge of inter-organellar communication has grown exponentially in recent years.
This review focuses on the interactions that cytoplasmic lipid droplets have with other …
This review focuses on the interactions that cytoplasmic lipid droplets have with other …
Lipid droplets as immune modulators in myeloid cells
MH den Brok, TK Raaijmakers, E Collado-Camps… - Trends in …, 2018 - cell.com
Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are
increasingly recognized as dynamic players in lipid metabolism, with important roles not …
increasingly recognized as dynamic players in lipid metabolism, with important roles not …
Foam cells: one size doesn't fit all
V Guerrini, ML Gennaro - Trends in immunology, 2019 - cell.com
Chronic inflammation in many infectious and metabolic diseases, and some cancers, is
accompanied by the presence of foam cells. These cells form when the intracellular lipid …
accompanied by the presence of foam cells. These cells form when the intracellular lipid …
Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response
Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events,
transient protein sequestration and inter-organelle interactions. However, the role LDs play …
transient protein sequestration and inter-organelle interactions. However, the role LDs play …
Pathogenicity and virulence of Mycobacterium leprae
M Sugawara-Mikami, K Tanigawa, A Kawashima… - Virulence, 2022 - Taylor & Francis
Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate
intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes …
intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes …
Emerging roles for lipid droplets in immunity and host-pathogen interactions
Lipid droplets (LDs) are neutral lipid storage organelles ubiquitous to eukaryotic cells. It is
increasingly recognized that LDs interact extensively with other organelles and that they …
increasingly recognized that LDs interact extensively with other organelles and that they …