Simple Summary Pediatric brain tumors represent a formidable challenge in the field of
oncology. Pediatric brain tumors are sub-classified into several molecular sub-types, where …

The birth of RNAi technology has pioneered actionability at the molecular level. Compared
to DNA, RNA is less stable and therefore requires more demanding delivery vehicles. With …

Pioneer transcription factors (TFs) regulate cell fate by establishing transcriptionally primed
and active states. However, cell fate control requires the coordination of both lineage …

SALL4, a member of the SALL family, is an embryonic stem cell regulator involved in self-
renewal and pluripotency. Recently, SALL4 overexpression was found in malignant cancers …

Although translational selection to favour codons that match the most abundant tRNAs is not
readily observed in humans, there is nonetheless selection in humans on synonymous …

Abstract The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial
regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) …

Abstract The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development
and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant …

Spalt-Like Transcription Factor 4 (SALL4) is a critical factor for self-renewal ability and
pluripotency of stem cells. On the other hand, various reports show tight relation of SALL4 to …

Cell fate decision involves rewiring of the genome, but remains poorly understood at the
chromatin level. Here, we report that chromatin remodeling complex NuRD participates in …

Simple Summary Transcription factors play essential roles in regulating gene expression,
impacting the cell phenotype and function, and in the response of cells to environmental …