Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

The γδ T cell lineage in humans remains much of an enigma due to the low number of
defined antigens, the non-canonical ways in which these cells respond to their environment …

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are
expanded in Plasmodium falciparum–infected patients. Although previous studies …

Increasing immunological knowledge and advances in techniques lay the ground for more
efficient and broader application of immunotherapies. gamma delta (γδ) T-cells possess …

Butyrophilin (BTN) and butyrophilin-like (BTNL/Btnl) heteromers are major regulators of
human and mouse γδ T cell subsets, but considerable contention surrounds whether they …

The complex tumor microenvironment is a most important factor in cancer development. The
biological microenvironment is composed of a variety of barriers including the extracellular …

Summary Vγ9Vδ2 T cells play critical roles in microbial immunity by detecting target cells
exposed to pathogen-derived phosphoantigens (P-Ags). Target cell expression of BTN3A1 …

Human Vγ9Vδ2 T cells respond to microbial infections and malignancy by sensing
diphosphate-containing metabolites called phosphoantigens, which bind to the intracellular …

Microbial diversity is associated with improved outcomes in recipients of allogeneic
hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this …