Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Drug‐induced toxicity is a key issue for public health because some side effects can be
severe and life‐threatening. These adverse effects can also be a major concern for the …

Nearly 2.3 million individuals worldwide are coinfected with human immunodeficiency virus
(HIV) and hepatitis C virus (HCV). Odds of HCV infection are six times higher in people living …

The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs
in the multidrug regimens used to treat HIV infection, in accordance with its well …

A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …

Lipodystrophy is a medical condition characterized by complete or partial loss of adipose
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …

Objective Liver fibrosis constitutes a major health problem worldwide due to its rapidly
increasing prevalence and the lack of specific and effective treatments. Growing evidence …

It has long been known that aging, at both the cellular and organismal levels, contributes to
the development and progression of the pathology of many chronic diseases. However …

Non-alcoholic fatty liver disease (NAFLD) has become the world's most common liver
disease. The disease can develop liver fibrosis or even carcinomas from the initial hepatic …